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KMID : 1145120190170010037
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Asian Journal of Beauty and Cosmetology
2019 Volume.17 No. 1 p.37 ~ p.46
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Melanogenesis Inhibitory Effect of Steamed Platycodon grandiflorum on B16F10 Cells
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Park Jeong-Yong
Lee Ji-Yeon
Lee Dae-Young
Kim Hyung-Don
Kim Geum-Soog
Lee Seung-Eun
Seo Kyung-Hye
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Abstract
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Purpose: This study aimed to investigate and compare effects of bioactive constituents in ethanol extracts of Platycodon grandiflorum (PG) using a threestep steaming process.
Method: The cell viability of PG and steamed PG extracts in α-MSH-induced B16F10 melanoma cells was investigated. Melanin content was determined, and western blotting was performed to examine the whitening effect of the steamed PG extracts.
Results: Treatment of α-melanocyte-stimulating hormone (α-MSH)-induced B16F10 melanoma cells with steamed PG (25?200 μg/mL) did not affect the cell viability. The steamed PG extracts effectively protected melanin formation. Furthermore, the steamed PG extract inhibited well-known melanin generation-related factors, such as tyrosinase and tyrosinase-related protein-1 (TRP- 1) and TRP-2.
Conclusion: The steamed PG extracts are potentially effective in suppressing melanin generation and related factors in α-MSH-induced B16F10 cells.
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KEYWORD
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Platycodon grandiflorum, Melanoma cell, Melanin content, Protein expression, Whitening
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